Allesandro Volta (1745-87)

Dev121434 1745..1755

Germ granules (P granules) in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency. Sterility in the absence of P granules is often accompanied by the misexpression of soma-specific proteins and the initiation of somatic differentiation in germ cells. To investigate whether this is caused by the accumulation of somatic transcripts, we performed mRNA...

Ddh180 1745..1754

Parkinson’s disease (PD) is characterized by the selective degeneration of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). A combination of genetic and environmental factors contributes to such a specific loss. Among the five PD-linked genes identified so far, parkin, a protein-ubiquitin E3 ligase, appears to be the most prevalent genetic factor in PD. Although a variety of ...

Op-brhe160243 1736..1745

Objective. RA typically features rheumatoid cachexia [loss of muscle mass (MM) and excessive total fat mass (TFM), especially trunk FM], which contributes to physical disability. Since rheumatoid cachexia is driven by inflammation, it would be anticipated that the success of tight control of disease activity, such as treat-to-target (T2T), in attenuating inflammation would benefit body composit...

The Volta Review Alexander Graham

A new perspective on GCRT J 1745 - 3009

Context. Reports on a transient source about 1.25 • south of the Galactic Centre motivated these follow-up observations with the WSRT and the reinvestigation of archival VLA data. The source GCRT J1745-3009 was detected during a 2002 Galactic Centre monitoring programme with the VLA at 92 cm by five powerful 10-min bursts with a 77-min recurrence while apparently lacking any interburst emission...